Transplantation. Jul 27;66(2) Uricosuric effect of the angiotensin II receptor antagonist losartan in heart transplant recipients. Minghelli G(1). This agent promotes uric acid excretion via effects on the organic anion transport The AIIA losartan also produces a uricosuric effect in healthy volunteers. Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act.

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Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy. Future prospective, randomized, placebo-controlled studies should include larger patient populations, and should explore more relatable and generalizable endpoints such as gout attack free periods or effecr of gout attacks.

Patients and clearance study in hypertensive patients. Febuxostat Inositols Phytic acid Myo-inositol Topiroxostat. Losartan was well tolerated and no participants experienced urate nephropathy [ Shahinfar et al.

This page was last edited on 21 Augustat These findings suggested that losartan inhibited URAT1 and thereby it lowered Sur levels in hypertensive patients. By using this site, you agree to the Terms of Use and Privacy Policy.

Irbesartan decreased serum uric acid levels from 7. Eight hypertensive subjects carrying the wild URAT1 gene matched for age and gender with five hypertensive hypouricemia patients were subjected to the benzbromarone and losartan tests.


Effect of benzbromarone on renal excretion of urate in URAT1-deficient hypouricemic patients distributed into those with normal Ccr and those with impaired Ccr.

The effect of ARBs on the occurrence of gout attacks or other clinical outcomes were not represented. Losartan has demonstrated renoprotective effects directly related to the degree of serum uric acid lowering; however, these endpoints were not explored in the included studies that enrolled patients with baseline hyperuricemia or a gout diagnosis [ Ito et al.

The hypotensive and uricosuric effect of valsartan compared to losartan in gout patients. Ann Intern Med More on this topic A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients: Five hypertensive outpatients with idiopathic renal hypouricemia 49 years old on average, three men and four normotensive outpatients with idiopathic renal hypouricemia all women whose average age was 56 were enrolled for this study.

Uricosuric action of losartan via the inhibition of urate transporter 1 URAT 1 in hypertensive patients.

Effect of losartan on renal excretion of urate in a hypouricemic losartab patient no. J Cardiovasc Pharmacol Related articles in Web of Science Google Scholar. There were no significant serum uric acid level increases at hours 2, 4 and 6 on day 1.


Uricosuric effect of losartan in patients with renal transplants.

Compared with the baseline uric acid level of 9. The lack of effect of URAT1 inhibitors on renal excretion of urate was independent of the renal function of hypouricemic patients. In the hydrochlorothiazide and losartan group, uric acid levels decreased from 8. Gout and its comorbidities. Losartan induced a significant reduction in Sur 6.

Uricosuric effect of losartan in patients with renal transplants.

Zanchetti A, Mancia G. Both drugs losartab well tolerated; however, there was one serious adverse effect noted in the study that was not described by the authors [ Rayner et al. Individuals had to be maintained on a stable dose of diuretics for at least 12 weeks before study entry.

Renal effects of angiotensin II receptor blockade in normotensive subjects. Interaction of nonpeptide angiotensin II receptor antagonists with the urate transport in rat renal brush-border membranes.

Urine uric acid excretion increased at hours 2, 4 and 6 on day 1. However, it is still unknown whether the fefect effect of losartan on URAT1 contributes to its uricosuric action in humans.

The centenary of blood pressure measurement: This study was a prospective, randomized, double-blind, crossover study design.

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